Question 8 - Hepatitis A Question Bank - National STD Curriculum

Hepatitis AQuestion 8/8

A 23-year-old cisgender man with one male sex partner presents to his primary care provider and reports that his partner was diagnosed with hepatitis A virus (HAV) infection 2 days ago. His last sexual contact with his partner was 8 days ago, and he denies any symptoms. He has not been vaccinated for hepatitis A. His medical history is significant for asthma and eczema.

Which on of the following is the recommended hepatitis A virus postexposure prophylaxis for this 23-year-old man?

Administer a single dose of monovalent hepatitis A vaccine now and give a second dose 6 to 18 months later

Administer hepatitis A immune globulin 0.02 mL/kg in a single dose now

Administer hepatitis A immune globulin 0.02 mL/kg in a single dose now and repeat in 4 weeks

No postexposure prophylaxis is recommended since more than 72 hours have elapsed since the last sexual contact with the individual diagnosed with acute hepatitis A

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Question Last Updated
August 16th, 2024

Table 1.
Recommendations for Postexposure Prophylaxis Following Exposure to Hepatitis A Virus (HAV)
Indication/Age Group	Risk Category/Health Status	HAV Vaccine	Immune Globulin
<1 year	Healthy	No	0.1 mL/kg body weight*
1-40 years	Healthy	1 dose^{^}	None
>40 years	Healthy	1 dose^{^}	0.1 mL/kg body weight^§
≥1 Year	Immunocompromised or chronic liver Disease	1 dose^{^}	0.1 mL/kg body weight^#
≥1 Year	Vaccine Contraindication**	No	0.1 mL/kg body weight*
Measles, mumps, and rubella vaccine should not be administered for at least 3 months after receipt of Immune globulin ^{^}A second dose is not required for postexposure prophylaxis; however, for long-term immunity, the hepatitis A vaccination series should be completed with a second dose at least 6 months after the first dose. ^§The provider’s risk assessment should determine the need for immune globulin administration. If the provider’s risk assessment determines that both vaccine and immune globulin are warranted, HepA vaccine and immune globulin should be administered simultaneously at different anatomic sites. ^#Vaccine and immune globulin should be administered simultaneously at different anatomic sites. *Life-threatening allergic reaction to a previous dose of hepatitis A vaccine, or allergy to any vaccine component.

Source:

Nelson NP, Link-Gelles R, Hofmeister MG, et al. Update: Recommendations of the Advisory Committee on Immunization Practices for Use of Hepatitis A Vaccine for Postexposure Prophylaxis and for Preexposure Prophylaxis for International Travel. MMWR Morb Mortal Wkly Rep. 2018;67:1216-1220. [PubMed Abstract]

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Which on of the following is the recommended hepatitis A virus postexposure prophylaxis for this 23-year-old man?

Recommendations for Postexposure Prophylaxis Following Exposure to Hepatitis A Virus (HAV)

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