A 22-year-old man who has sex with men and women presents to clinic with a 2-day history of fevers, malaise, and a painful swelling in his right groin. The day prior to the clinic visit, he noticed multiple painful vesicles in the urethral opening and glans of his penis as well as tender adenopathy in his groin. On examination, he has multiple small vesicles on the penile glans and in the urinary meatus. A sample from one of the lesions is sent for herpes simplex virus (HSV) polymerase chain reaction (PCR) testing. He has no prior history of any genital or oral lesions. A diagnosis of first-episode genital herpes simplex virus (HSV) infection is strongly suspected, with a plan to initiate empiric treatment for HSV.