A 19-year-old cisgender man presents to clinic with a 2-day history of fevers, malaise, and a painful swelling in his right groin. About 12 hours prior to the clinic visit, he noticed multiple painful vesicles in the urethral opening and glans of his penis. He had insertive vaginal intercourse without a condom with a new sex partner about 7 days ago. On examination, he has multiple small vesicles on the penile glans and in the urinary meatus. A sample from one of the lesions is sent for herpes simplex virus (HSV) polymerase chain reaction (PCR) testing. He has no prior history of any genital or oral lesions. A diagnosis of first-episode genital herpes simplex virus (HSV) infection is strongly suspected with a plan to initiate empiric treatment for HSV.