Question 1 - Penicillin Allergy Question Bank

Penicillin AllergyQuestion 1/10

Urticaria (hives) and wheezing that begins within 1 hour

Skin rash with fever that begins in 24 to 48 hours

Allergic interstitial nephritis that begins after 48 to 72 hours

Skin rash that begins in about 10 days and progresses to Stevens-Johnson syndrome over the following 3 days

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Question Last Updated
March 13th, 2025

Table 1.
Gell and Coombs Classification of Hypersensitivity Reactions
Type of Reactions	Hypersensitivity	Mediated by	Time of Onset	Examples
IgE-mediated	Type I	IgE antibodies	Within 1 hour	Anaphylaxis
Non-IgE-mediated	Type II	Cytotoxic	Hours to days	Hemolytic anemia
Non-IgE-mediated	Type III	Immune complex	7-21 days	Serum sickness
Non-IgE-mediated	Type IV	Cell-mediated	Days to weeks	Maculopapular rash Stevens-Johnson syndrome Toxic epidermal necrolysis
IgE = immunoglobulin E

Source:

Gonzalez-Estrada A, Radojicic C. Penicillin allergy: A practical guide for clinicians. Cleve Clin J Med. 2015;82:295-300. [PubMed Abstract]