A 24-year-old woman is diagnosed with cervicitis. Samples are sent for nucleic acid testing for Neisseria gonorrhoeae and Chlamydia trachomatis. She has a negative pregnancy test, and the plan is to treat her with ceftriaxone and doxycycline. On further questioning, she reports having an allergic reaction to penicillin as a child, manifested as hives.
Which one of the following statements is TRUE when considering the use of ceftriaxone in this woman with a history of penicillin allergy?
Figure 1. Penicillin and Cephalosporin Structures and Cross Reactivity
In this figure, the beta-lactam ring is outlined in green, the thiazolidine and dyhydrothiazine rings are outlined in yellow, the side chain (or R group with R1 location) is highlighted by the orange circle, and the R2 location is shown by the gray circle.
Source: Khan DA, Banerji A, Blumenthal KG, et al. Drug allergy: A 2022 practice parameter update. J Allergy Clin Immunol. 2022 150:1333-93.
This figure was reproduced with permission from Elsevier (www.jacionline.org)
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Question Last Updated
March 13th, 2025
March 13th, 2025
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