Table 1. 2021 STI Treatment Guidelines: EpididymitisTreatment of Epididymitis
Recommended
for acute epididymitis most likely caused by chlamydia or gonorrhea
Ceftriaxone500 mg* IM in a single dose for persons weighing <150 kg
Ceftriaxone
Tradename:RocephinDoxycycline100 mg orally 2 times/day for 10 days+
Doxycycline
Tradename:Doryx, VibramycinNote: *For persons weighing ≥150 kg, ceftriaxone 1 g IM should be administered.
Recommended
for acute epididymitis most likely caused by chlamydia, gonorrhea, or enteric organisms (men who practice insertive anal sex)
Ceftriaxone500 mg* IM in a single dose for persons weighing <150 kg
Ceftriaxone
Tradename:RocephinLevofloxacin500 mg orally once daily for 10 days+
Levofloxacin
Tradename:LevaquinNote: *For persons weighing ≥150 kg, ceftriaxone 1 g IM should be administered.
Recommended
for acute epididymitis most likely caused by enteric organisms only
Levofloxacin500 mg orally once daily for 10 days
Levofloxacin
Tradename:LevaquinSource: Workowski KA, Bachmann LH, Chan PA, et al. Sexually transmitted infections treatment guidelines, 2021. Epididymitis. MMWR Recomm Rep. 2021;70(No. RR-4):1-187. [2021 STI Treatment Guidelines]