Table 1. 2021 STI Treatment Guidelines: Mycoplasma genitaliumRecommended Regimens if M. genitalium Resistance Testing is Available
Recommended
if macrolide sensitive:
Doxycycline followed by AzithromycinDoxycycline 100 mg orally 2 times/day for 7 days, followed by Azithromycin 1 g orally initial dose, followed by 500 mg orally once daily for 3 additional days (2.5 g total of Azithromycin)
Doxycycline followed by Azithromycin
Tradename:
Recommended
if macrolide resistant:
Doxycycline followed by MoxifloxacinDoxycycline 100 mg orally 2 times/day for 7 days, followed by Moxifloxacin 400 mg orally once daily for 7 days
Doxycycline followed by Moxifloxacin
Tradename:Source: Workowski KA, Bachmann LH, Chan PA, et al. Sexually transmitted infections treatment guidelines, 2021. Mycoplasma genitalium. MMWR Recomm Rep. 2021;70(No. RR-4):1-187. [2021 STI Treatment Guidelines]
Table 2. 2021 STI Treatment Guidelines: Mycoplasma genitaliumRecommended Regimens if M. genitalium Resistance Testing is Not Available
Recommended
if M. genitalium is detected by an FDA-cleared NAAT:
Doxycycline followed by MoxifloxacinDoxycycline 100 mg orally 2 times/day for 7 days, followed by Moxifloxacin 400 mg orally once daily for 7 days
Doxycycline followed by Moxifloxacin
Tradename:Source: Workowski KA, Bachmann LH, Chan PA, et al. Sexually transmitted infections treatment guidelines, 2021. Mycoplasma genitalium. MMWR Recomm Rep. 2021;70(No. RR-4):1-187. [2021 STI Treatment Guidelines]