A 25-year-old woman is seen for a new evaluation of anal warts. Testing for HIV is negative.
Which one of the following best describes recommendations regarding indications for performing biopsy of anogenital warts?

Figure 1. Perianal Condylomas with Atypical Characteristics: Pigmentation Changes
This image from high-resolution anoscopy (magnification 15x) shows perianal condyloma with a specific area (yellow circles) demonstrating hyperpigmentation and hypopigmentation. Biopsy of the lesion confirmed high-grade squamous epithelial lesion.
Photograph credit: Helen C. Stankiewicz Karita, MD

Figure 2. Perianal Condylomas with Atypical Characteristics: Pigmentation Changes
Circumferential perianal condylomas with hypo- and hyperpigmentation and areas with superficial ulceration. Biopsy of the lesion confirmed high-grade squamous epithelial lesion.
Photograph credit: Helen C. Stankiewicz Karita, MD
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Question Last Updated
February 4th, 2025
February 4th, 2025
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