A 42-year-old man is evaluated at a sexual health clinic with a 3-week history of anal pruritus and bleeding after receptive anal sex. He reports having unprotected receptive anal intercourse with 5 male partners in the past 12 months. Physical examination reveals multiple external anal warts. On anoscopy, several internal warts are visualized. Additional testing is negative for HIV, syphilis, gonorrhea, and chlamydia.
Which one of the following statements is TRUE regarding intra-anal warts?

Figure 1. Intra-Anal Warts and High-Grade Squamous Intra-Epithelial Lesion
This image shows multiple condylomas and high-grade squamous intra-epithelial lesion (yellow circle) in the anal canal.
Photograph credit: Helen C. Stankiewicz Karita, MD
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Question Last Updated
February 4th, 2025
February 4th, 2025
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