An 18-year-old woman is evaluated in a sexual health clinic with several days of vaginal pain. During the evaluation, she reported attending a party 5 nights ago and blacking out after consuming one mixed drink. Later that evening, one of her friends found her deeply asleep in a bedroom with her clothing in disarray. She does not remember anything that happened, but she and her friend believe she was drugged and sexually assaulted. She was traumatized by the incident and has avoided seeking medical care. The clinician performs a sexual assault examination and obtains appropriate laboratory studies. As part of the comprehensive evaluation and treatment, HIV postexposure prophylaxis (PEP) is discussed with her.