A 27-year-old woman who is 24 weeks of gestation is diagnosed with secondary syphilis based on a history of a diffuse erythematous macular rash, a positive syphilis enzyme immunoassay (EIA), and a positive Venereal Diseases Research Lab (VDRL) titer of 1:128.
In addition to the plan to provide the mother appropriate antimicrobial treatment for syphilis, what other evaluation should be recommended at this time?
Figure 1. Frequency of Fetal Ultrasound Abnormalities in 73 Pregnant Women With Syphilis
*More than 1 abnormality may have been present on an individual ultrasound.
This retrospective review analyzed records from 235 women diagnosed with syphilis at 18 weeks or greater of gestation who had a fetal ultrasound performed to evaluate for fetal syphilis (before maternal syphilis treatment). This graphic shows frequency of fetal abnormalities among the 73 ultrasounds that had at least one abnormal finding.
This retrospective review analyzed records from 235 women diagnosed with syphilis at 18 weeks or greater of gestation who had a fetal ultrasound performed to evaluate for fetal syphilis (before maternal syphilis treatment). This graphic shows frequency of fetal abnormalities among the 73 ultrasounds that had at least one abnormal finding.
Source: Rac MW, Bryant SN, McIntire DD, et al. Progression of ultrasound findings of fetal syphilis after maternal treatment. Am J Obstet Gynecol. 2014;211:426.e1-6.
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Question Last Updated
February 4th, 2025
February 4th, 2025
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