A 32-year-old man presents to a clinic for evaluation of a rash. He denies taking any new medications and reports 2 new male sex partners in the last 8 weeks. The rash began several days prior as an erythematous, maculopapular rash on the chest and back (Figure 1) and now also involves the palms and soles. He does not have any ocular, otic, or neurologic symptoms. Serologic testing for syphilis and HIV is ordered. He does not report any drug allergies.
Which one of the following antibiotics is the most appropriate for the treatment of presumed secondary syphilis?
Figure 1. Secondary Syphilis: Maculopapular Rash on Back
Source: photograph by Negusse Ocbamichael, PA; Public Health—Seattle & King County Sexual Health Clinic
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Question Last Updated
March 16th, 2025
March 16th, 2025
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