A 19-year-old transgender woman is seen in sexual health clinic to discuss possibly starting HIV preexposure prophylaxis (PrEP). She has sex with men and intermittently uses condoms. As part of the initial evaluation, testing is ordered for HIV, chlamydia, gonorrhea, and syphilis.
Which one of the following is TRUE regarding serologic testing for syphilis?
Figure 1. Examples of Decreases in Syphilis Titers
1 = first sample; 2 denotes second sample
Note the fold change is determined by dividing the larger number by the smaller and then stating whether it was an increase or decrease. See example 3: the larger number 32 divided by the smaller number 4 would be 8. Since the titer decreased, this would be an eightfold decrease in titer.
Illustration: David H. Spach, MD
Figure 2. Examples of Increases in Syphilis Titers
1 = first sample; 2 denotes second sample
Note the fold change is determined by dividing the larger number by the smaller and then stating whether it was an increase or decrease in titer. See example 2: the larger number 32 divided by the smaller number 8 would be 4. Since the titer increased, this would be an fourfold increase in titer.
Illustration: David H. Spach, MD
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Question Last Updated
November 4th, 2021
November 4th, 2021
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