A 35-year-old woman presents with a 5-day history of severe vaginal itching and pain during urination. She denies fevers, chills, or pelvic pain. She is sexually active with one man, and they consistently use condoms. She has been diagnosed with vulvovaginal candidiasis four times in the past 12 months, for which she has received multiple courses of oral fluconazole (150 mg single dose). On physical examination, vulvar erythema and thick white vaginal discharge are visualized. Budding yeasts are seen on a Gram stain of a wet mount on a sample taken from the vagina, and a vaginal discharge fungal culture subsequently grows Candida glabrata.
Although the optimal therapy for non-albicans vulvovaginal candidiasis remains unknown, which one of the following agents should be considered as an initial option to treat Candida glabrata vulvovaginal infection in this woman?
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Question Last Updated
March 10th, 2025
March 10th, 2025
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